voriconazole will improve the stage or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Headache, intermittent claudication, muscle pains, numbness, or coldness and pallor with the digits might come about with Serious intoxication; When the issue is allowed to progress untreated, gangrene can result
ergotamine will boost the amount or result of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
atazanavir will enhance the degree or effect of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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Coadministration with CYP3A4 substrates, notably those which has a narrow therapeutic index, can lead to reduced concentrations and loss of efficacy. If struggling to steer clear of coadministration, monitor CYP3A4 substrate amounts and alter dose as needed.
Contraindicated. Nirmatrelvir/ritonavir is contraindicated with medicine that happen to be hugely dependent on CYP3A for clearance and for which elevated concentrations are affiliated with critical and/or life-threatening reactions.
ketoconazole will enhance the level or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Though a click here thienodiazepine, etizolam is clinically viewed as a benzodiazepine thanks to its manner of action through the benzodiazepine receptor and immediately targeting GABAA allosteric modulator receptors.[five]
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pirtobrutinib will boost the degree or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Voxelotor increases systemic exposure of delicate CYP3A4 substrates. Steer clear of coadministration with sensitive CYP3A4 substrates which has a narrow therapeutic index. Look at dose reduction of the sensitive CYP3A4 substrate(s) if unable to keep away from.
Stay clear of concomitant usage of tucatinib with CYP3A substrates, exactly where nominal concentration adjustments may possibly cause critical or lifetime-threatening toxicities. If unavoidable, lower CYP3A substrate dose according to products labeling.
Nirmatrelvir/ritonavir is contraindicated with medication which have been extremely dependent on CYP3A for clearance and for which elevated concentrations are connected to major and/or lifestyle-threatening reactions.